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KMID : 0361020200630010026
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Korean Journal of Otolaryngology - Head and Neck Surgery
2020 Volume.63 No. 1 p.26 ~ p.30
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Impact of the Preoperative Neutrophil to Lymphocyte Ratio on Patients with Head and Neck Cancer
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Kim Geun-Jeon
Kang Jun-Myung
Seo Jae-Hyun
Hwang Se-Hwan
Youn Ho-Young
Jin Ho-Jun
Kang Ha-Ram
Lee Hyun-Ho
Joo Young-Hoon
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Abstract
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Background and Objectives: To investigate the prognostic value of the neutrophil to lymphocyte ratio (NLR) in patients with head and neck squamous cell cancer (HNSCC).
Subjects and Method: Clinical data from 259 patients with HNSCC were collected retrospectively. NLR was adopted as potential prognostic biomarkers.
Results: NLR was associated with cancer recurrence (p=0.002 and p＜0.001, respectively). Patients with a NLR ＞2.15 had significantly decreased 5-year disease specific survival (DSS) based on the Kaplan-Meier survival curves (p＜0.001 and p=0.029, respectively). The Multivariate Cox regression analysis confirmed a significant association between 5-year DSS and the NLR (using 2.15 as the cut-off; hazard ratio, 1.852; 95% confidence interval, 1.237-2.771; p= 0.003).
Conclusion: A NLR cut-off value ≥2.15 was associated with adverse outcomes in patients with HNSCC.
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KEYWORD
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Head and neck neoplasms, Hematologic tests, Prognosis, Recurrence, Squamous cell carcinoma
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